-Klotho and FGF-15/19 inhibit the apical sodium-dependent bile acid transporter in enterocytes and cholangiocytes
نویسندگان
چکیده
Jyoti Sinha,* Frank Chen,* Tamir Miloh, Robert C. Burns, Zhisheng Yu, and Benjamin L. Shneider Department of Pediatrics, Mount Sinai School of Medicine, New York, New York; Division of Gastroenterology, Hepatology and Nutrition, Children’s Hospital of Pittsburgh of University of Pittsburgh Medical Center; and Department of Pediatrics and the Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
منابع مشابه
beta-Klotho and FGF-15/19 inhibit the apical sodium-dependent bile acid transporter in enterocytes and cholangiocytes.
beta-Klotho, a newly described membrane protein, regulates bile acid synthesis. Fibroblast growth factor-15 (FGF-15) and FGF receptor-4 (FGFR4) knockout mice share a similar phenotype with beta-Klotho-deficient mice. FGF-15 secretion by the intestine regulates hepatic bile acid biosynthesis. The effects of beta-Klotho and FGF-15 on the ileal apical sodium bile transporter (ASBT) are unknown. be...
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Submit Manuscript | http://medcraveonline.com Abbreviations: BAM: Bile Acid Malabsorption; CA: Cholic Acid; CDCA: Chenodeoxycholic Acid; DCA: Deoxycholic Acid; ASBT: Apical Sodium-dependent Bile Acid Transporter; IBS-D: Diarrhea-Predominant Irritable Bowel Syndrome; SeHCAT: Selenium HomotauroCholic Acid Test, FGF: Fibroblast growth factor; GPBAR1: G Protein-coupled Bile Acid Receptor 1; CYP7A1:...
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